The role of PD1+ CD8+ suppressor T cells in nest of oral squamouscell carcinoma

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Regulatory T cells are known to suppress tumore immunity in tumor tissues.In recent years, the role of CD8+ T cells has attracted attention in addeition to CD4+ regulator y T cells. Accordingly, the relationship between local CD8+ T ccells in oral squamous cell carcinoma and the pathological condieion thereof was investigated. As a result, it was found that PD -1+ CD8+ T cells, which make up a regulatory lymphocyte subset, were specifically invading inside the cancer cell nest of oral squmous cell carcinoma. This is in contrast to the presence of CD4+ regulatory T cells in the stroma of cancer, and it has been suggested that PD-1+ CD8+ T cells and CD4+ regulatory T cells in the stroma of cancer, and it has been suggested that PD-1+ CD8+ T cells and CD4+ regulatory T cells play different roles regarding the immunosuppression of tumors.