Examination of the dendritic cell vaccination in oral cancer adjuvant postoperative treatment

结论：1.头颈部癌组织中Bcl一2和Bax基因的表达可作为判断预后的有用指标。5-FU可能通过调节PD-L1和PD-L2的表达来增强树突状细胞的T细胞刺激能力，DC肿瘤疫苗与5-FU联合治疗可能比单独接种具有更好的抗肿瘤效果。以OK-432为基础的免疫治疗显著提高了口腔鳞癌患者放化疗的疗效，但也阐明了5-FU和放疗通过抑制SOCS1和SOCS3基因的表达而增强OK-432诱导的Th1应答的协同作用机制。

1. The expression of the genes of Bcl-2 and Bax may be useful prognostic factor in head and neck cancer patients.2. The possibility that 5-FU may enhance the T cell-stimulatingability of dendritic cells via regulation of the expression of PD-L1 and PD-L2, and that the combination therapy of DC-based cancer vaccine with 5-FU may elicit better anti-tumor efficacy than only vaccination.3. OK-432-based immunotherapy significantly enhanced therapeutic effects of chemoradiotherapy in patients with oral squamous cell carcinoma, but also elucidating mechanism of synergic effect of the immuno-chemoradiotherapy that 5-FU and radiation enhanced OK-432-induced Th1 response mediated by inhibition of expression of SOCS1 and SOCS3genes.