Influences of sex hormone and growth factors on craniofacial bone growth

性激素和生长因子对颅面骨生长的影响

• 批准号: 23792430
• 负责人: OHTANI Junji
• 金额: $ 2.66万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792430/
• 关键词: 歯学; 動物; 性ホルモン; 顎顔面骨格; 成長発育; エストロゲン; アンドロゲン; 骨成長発育; 国際情報交流

It applied in the first half of adolescence from immediately after birth, E2 affect ER-beta Receptor as the main course and it has had influence to a cartilage and osteoblast cells in female, In the second half of adolescence, the activity of ER-alpha Receptor increased with aging, and a possibility that E2 influence ER-alpha Receptor as the main course was suggested. Moreover, in male, in the first half of adolescence from immediately after birth, DHT production increased rather than E2, and a possibility that bone growth would enhancesaccording to the course through AR-Receptor was suggested, having applied E2 in the second half of the adolescence of what makes ER-beta Receptor the main course.

在青春期的前半期，雌激素（E_2）对雌激素受体（ER-α）的影响主要是以雌激素（E_2）影响ER-β受体为主，对女性的软骨和成骨细胞也有影响。此外，在男性中，从出生后即刻开始的青春期前半期，DHT的产生增加而不是E2，并提出了骨生长通过AR-受体的过程而增强的可能性，在青春期后半期应用E2使ER-β受体成为主要过程。

项目成果

A newly developed snack effective for enhancing bone volume.

一种新开发的零食，可有效增强骨骼体积。

• DOI: 10.1186/1475-2891-8-30
• 发表时间: 2009-07-03
• 期刊: Nutrition journal
• 影响因子: 5.4
• 作者: Ohtani J;Hernandez RA;Sunagawa H;Fujita T;Kawata T;Kaku M;Motokawa M;Tsuka N;Koseki H;Matsuda Y;Hayashi H;Abedini S;Tanne K
• 通讯作者: Tanne K

Mandibular and femoral growth alternation after sex hormone disruption in growing mice.

生长中的小鼠性激素破坏后下颌骨和股骨的生长交替。

• DOI: 10.1111/j.1601-6343.2011.01509.x
• 发表时间: 2011
• 期刊: Orthodontics and Craniofacial Research
• 影响因子: 3.1
• 作者: Marquez Hernandez RA.;Junji Ohtani
• 通讯作者: Junji Ohtani

Sex hormones receptors play a crucial role in the control of femoral and mandibular growth in newborn mice

• DOI: 10.1093/ejo/cjq124
• 发表时间: 2011-10-01
• 期刊: EUROPEAN JOURNAL OF ORTHODONTICS
• 影响因子: 2.6
• 作者: Marquez Hernandez, R. A.;Ohtani, J.;Tanne, K.
• 通讯作者: Tanne, K.