A newly developed snack effective for enhancing bone volume.
A newly developed snack effective for enhancing bone volume.
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一种新开发的零食，可有效增强骨骼体积。
DOI：
10.1186/1475-2891-8-30
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发表时间：
2009-07-03
影响因子：
5.4
通讯作者：
Tanne K
中科院分区：
文献类型：
--
作者：
Ohtani J;Hernandez RA;Sunagawa H;Fujita T;Kawata T;Kaku M;Motokawa M;Tsuka N;Koseki H;Matsuda Y;Hayashi H;Abedini S;Tanne K
原发性骨质疏松症在日本的发病率高于美国和欧洲国家。近年来，骨科领域逐渐认识到预防医学的重要性，认为应尽可能提高儿童期骨量峰值，以预防骨质疏松症。在这样的背景下，我们开发了一种新的豆类零食，旨在改善骨质流失。在本研究中，我们研究了一种新开发的零食对骨质疏松模型小鼠骨量和骨密度的影响。本实验采用12周龄C57BL/6J小鼠（Jackson Laboratory, Bar Harbar， ME， USA）行睾丸切除术（ORX）和卵巢切除术（OVX）。配制并饲喂正常钙饲粮（NCD, Ca: 0.9%, Clea Japan Co.，东京）、低钙饲粮（LCD, Ca: 0.63%, Clea Japan Co.,）和特殊饲粮（SCD, Ca: 0.9%） 3种粉饲粮。术后18周，处死所有大鼠，进行组织形态学分析，定量测定骨密度和骨矿物质含量。组织形态学检查结果显示，SCD不分年龄和性别都能增加骨体积。骨质疏松模型小鼠与对照小鼠相比，新发育的零食使骨质疏松模型小鼠骨密度显著增加。骨矿物质含量也显著提高。这些现象在两性中都有体现。研究表明，新开发的豆类零食对改善骨量损失是非常有效的，无论性别。我们证明了新开发的零食补充剂可能是一种有效的预防措施，日本人的骨密度值低于理想状态。
The incidence of primary osteoporosis is higher in Japan than in USA and European countries. Recently, the importance of preventive medicine has been gradually recognized in the field of orthopaedic surgery with a concept that peak bone mass should be increased in childhood as much as possible for the prevention of osteoporosis. Under such background, we have developed a new bean snack with an aim to improve bone volume loss. In this study, we examined the effects of a newly developed snack on bone volume and density in osteoporosis model mice. Orchiectomy (ORX) and ovariectomy (OVX) were performed for C57BL/6J mice of twelve-week-old (Jackson Laboratory, Bar Harbar, ME, USA) were used in this experiment. We prepared and given three types of powder diet e.g.: normal calcium diet (NCD, Ca: 0.9%, Clea Japan Co., Tokyo, Japan), low calcium diet (LCD, Ca: 0.63%, Clea Japan Co.,) and special diet (SCD, Ca: 0.9%). Eighteen weeks after surgery, all the animals were sacrified and prepared for histomorphometric analysis to quantify bone density and bone mineral content. As a result of histomorphometric examination, SCD was revealed to enhance bone volume irrespective of age and sex. The bone density was increased significantly in osteoporosis model mice fed the newly developmental snack as compared with the control mice. The bone mineral content was also enhanced significantly. These phenomena were revealed in both sexes. It is shown that the newly developed bean snack is highly effective for the improvement of bone volume loss irrespective of sex. We demonstrated that newly developmental snack supplements may be a useful preventive measure for Japanese whose bone mineral density values are less than the ideal condition.
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影响因子：
9.8
作者：
Fujioka, Maiko;Sudo, Yumi;Ishimi, Yoshiko
通讯作者：
Ishimi, Yoshiko
DOI：
10.1024/0300-9831.76.3.111
发表时间：
2006-05-01
影响因子：
2.3
作者：
Matsuzaki, Hiroshi;Miwa, Misao
通讯作者：
Miwa, Misao
影响因子：
4.8
作者：
Miyauchi, A;Notoya, K;Fujita, T
通讯作者：
Fujita, T
影响因子：
2.1
作者：
Yamamoto, T;Kubo, T;Sueishi, K
通讯作者：
Sueishi, K
影响因子：
5.8
作者：
Schoenau, E.;Fricke, O.
通讯作者：
Fricke, O.