Association between Helicobacter pylori infection with atrophic gastritis and lifestyle: a general population-based cohort study

幽门螺杆菌感染与萎缩性胃炎和生活方式之间的关联：基于一般人群的队列研究

• 批准号: 23792684
• 负责人: KURAUCHI Shizuka
• 金额: $ 2.75万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792684/
• 关键词: ヘリコバクター・ピロリ感染; 萎縮性胃炎; 生活習慣

An association between incidence of stomach cancer and Helicobacter pylori (Hp)-induced atrophic gastritis (AG) has been reported in a number of previous studies. In this Japanese general population-based study, we examined the relationship between Hp infection with AG and lifestyle. Subjects included participants from a health promotion project who were infected with Hp without AG in 2007 (n=41). They were divided into the maintenance group (AG(-), n=35) and the progression group (AG(+), n=6) according to the AG state in 2012. In many maintenance group, there were many subjects who underwent with eradication therapy of Hp, which could prevent progression of AG. No significant differences were seen between groups in lifestyle data; however, significant differences were evident in dietary intake of milk and fish with less fat in the previous month. Relationships between food and mucosal atrophy should be examined for gastric cancer prevention.

幽门螺杆菌（Helicobacter pylori，Hp）引起的萎缩性胃炎（atrophic gastritis，AG）与胃癌发病率之间的相关性已被大量研究报道。在这项以日本普通人群为基础的研究中，我们研究了幽门螺杆菌感染与AG和生活方式之间的关系。受试者包括健康促进项目的参与者，他们在2007年感染了Hp，但没有AG（n=41）。根据2012年AG状态分为维持组（AG（-），n=35）和进展组（AG（+），n=6）。在许多维持组中，有许多受试者接受了根除Hp的治疗，这可以防止AG的进展。在生活方式数据方面，两组之间没有显着差异;然而，在前一个月的牛奶和脂肪较少的鱼的饮食摄入量方面存在显着差异。食物和粘膜萎缩之间的关系应检查胃癌的预防。

项目成果

Association Between Helicobacter Pylori Infection And Atrophic Gastritis, and Serum Selenium Concentration

幽门螺杆菌感染与萎缩性胃炎及血清硒浓度的关系

• 发表时间: 2012
• 期刊: The Hirosaki Medical Journal
• 作者: Shizuka Kurauchi;Ippei Takahashi;Masashi Matsuzaka;Kaori Iwane;Kazuma Danjo;Mariko Semato;Manabu Hamano;Terumi Kogawa;Takashi Umeda;Shigeyuki Nakaji
• 通讯作者: Shigeyuki Nakaji