Sesquiterpenoide und andere biologisch aktive Marker-Verbindungen in bulgarischen Achillea-millefolium-Arten

保加利亚蓍草中的倍半萜类化合物和其他生物活性标记化合物

• 批准号: 5409531
• 负责人: Professor Dr. Helmut Duddeck
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2003
• 资助国家: 德国
• 起止时间: 2002-12-31 至 2005-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5409531?language=en
• 关键词: Sesquiterpenoide; und; andere; biologisch; aktive

The purpose of this project is a comparative phytochemical study of the Bulgarian plant species of Achillea millefolium group (yarrow) used in folk medicine, with the view of identifying the main biologically active components and elucidating the structure of the unknown compounds. A special attention will be paid on the sesquiterpene lactones, as they are recognized to be the active principles in yarrow. The lactone-containing fractions will be submitted to separation using modern chromatographic techniques, and the individual compounds will be characterized by spectroscopic methods. The less polar fractions of the total plant extracts will be also investigated from both chemical and biological point of view. The plant species with the highest content of proazulenes and significant biological activity will be recommended for cultivation.

该项目的目的是对民间医药中使用的保加利亚植物千叶草属（西洋蓍属）物种进行植物化学比较研究，以期查明主要的生物活性成分，并阐明未知化合物的结构。特别注意的是倍半萜内酯，因为他们被认为是在西洋蓍的有效成分。将使用现代色谱技术对含内酯的馏分进行分离，并通过光谱方法对单个化合物进行表征。还将从化学和生物学的角度研究总植物提取物的极性较小的部分。将推荐前甘菊环含量最高、生物活性显著的植物品种进行种植。