Analysis of Plant Pathogen Resistance Supported by the ER Body

内质网(ER)小体是拟南芥体内积累的内质网衍生结构。内质网小体参与植物抵御病虫害的防御系统，因为创伤处理诱导了内质网小体。两种可溶性蛋白NAI2和PYK10，以及两种完整的膜蛋白MEB1和MEB2特异性地聚集在内质网小体中，但它们的功能尚不清楚。我发现NAI2和PYK10负责内质网小体的形成。MEB1和MEB2具有铁/锰转运活性，提示内质网小体参与了金属应力抗性。这些发现没有揭示植物内质网小体形成和功能的独特机制

Endoplasmic reticulum (ER) body is an ER derived structure that is accumulated in Arabidopsis thaliana. ER body is involved in plant defense system against insect and pathogen attack, since wound treatment induced ER bodies. Two soluble proteins NAI2 and PYK10, and two integral membrane proteins MEB1 and MEB2 are accumulated specifically in ER bodies, but their functions were obscure. I found that NAI2 and PYK10 are responsible for the ER body formation. MEB1 and MEB2 have iron/manganese transport activity, suggesting that ER body is involved in the metal stress resistance. These findings unrevealed unique mechanisms for ER body formation and function in plants