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Analysis of the molecular properties of vertebrate novel UV-absorbing proteins

Analysis of the molecular properties of vertebrate novel UV-absorbing proteins
脊椎动物新型紫外线吸收蛋白的分子特性分析
批准号:
23770074
负责人:
YAMASHITA Takahiro
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
We analyzed the molecular properties of Opn5 group which contains photoreceptive proteins widely distributed in vertebrates. We revealed that, among several subgroups of Opn5 group, Opn5m and Opn5L2 can bind 11-cis-retinal to form UV-sensitive pigments and photoisomerization into all-trans-retinal results in G protein activation. In addition, non-mammalian Opn5m and Opn5L2 can also directly bind all-trans-retinal to activate G protein without light irradiation. These data suggest that Opn5 proteins possibly provide the molecular basis for UV reception in vertebrates including humans and non-mammalian Opn5 proteins are also responsible for non-photoreceptive function.
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DOI: 10.1371/journal.pone.0031534
发表时间: 2012
期刊: PloS one
影响因子: 3.7
作者: [Ohuchi H, Yamashita T, Tomonari S, Fujita-Yanagibayashi S, Sakai K, Noji S, Shichida Y]
通讯作者: Shichida Y
非哺乳類特異的なオプシン5類似光受容タンパク質の解析
非哺乳动物特异性视蛋白 5 样光感受器蛋白的分析
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Ikeda A., Matsuoka S., Masuya H., Mori A.S., Hirose D. & Osono T., 山下高廣・大内淑代・友成さゆり・柳林(藤田)彩理・酒井佳寿美・野地澄晴・七田芳則]
通讯作者: 山下高廣・大内淑代・友成さゆり・柳林(藤田)彩理・酒井佳寿美・野地澄晴・七田芳則
マウスメラノプシンの光応答特性
小鼠黑视蛋白的光响应特性
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kazumi Saikusa, Naoyuki Kuwabara, Yuichi Kokabu, Mamoru Sato, Hiroshi Iwasaki, Mitsunori Ikeguchi, Toshiyuki Shimizu, and Satoko Akashi, A. Fukuyama, 菊池潔・甲斐渉, 松山オジョス武]
通讯作者: 松山オジョス武
Functional evolution of opsins
视蛋白的功能进化
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Miyazawa, T., Nakagawa, K., Kimura, F., Satoh, A., Miyazawa, T., T. Yamashita]
通讯作者: T. Yamashita
36
    Development of bioelectrochemical system using microorganisms involved in the sulfur cycle
    Functional analysis of dimer formation of G protein-coupled receptors, rhodopsin
    • 批准号:
      19770130
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.44万
    • 财政年份:
      2007
    • 负责人:
      YAMASHITA Takahiro
    • 依托单位:
    海外基金