Study on regulatory mechanisms of the expression and secretion of insulin-like peptides

利用果蝇和哺乳动物胰腺β细胞来源细胞系分析了胰岛素样肽（ILPs）功能的调控机制。我们发现了Dachshund和eyeeless两个转录因子对胰岛素表达的进化保守调控机制。我们进一步鉴定了一种新的ILPs结合蛋白，称为分泌诱饵InR (SDR)，它与循环血淋巴中的ILPs结合，并在发育过程中拮抗胰岛素/IGF信号。

Regulatory mechanisms of the function of insulin-like peptides (ILPs) were analyzed by using fruit fly Drosophila melanogaster and mammalian pancreatic β cells-derived cell line. We found that the evolutionally conserved regulatory mechanism of the insulin expression by two transcriptional factors, Dachshund and Eyeless. We further characterized a novel ILPs-binding protein called secreted decoy of InR (SDR) that binds to ILPs in the circulating hemolymph and antagonizes insulin/IGF signaling during development.