Molecular mechanism of repression of rDNA transcription by KDM2A in response to starvation
Molecular mechanism of repression of rDNA transcription by KDM2A in response to starvation
批准号:
23770209
负责人:
TANAKA Yuji
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
In previous study, we found that histone demethylase KDM2Adecreases histone H3K36me2 on rDNA promoter and represses rDNA transcription during starvation. Here, I had researched about molecular mechanisms of KDM2A to repress rDNA transcription. I showed that insulin or glucose treatment suppressed demethylation activity of KDM2A in rDNA promoter and repression of rDNA transcription in starved cells. Moreover, CXXC domain in KDM2A was required to demethylate H3K36me2 in rDNA promoter and to repress rDNA transcription during starvation.
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rRNA転写調節酵素KDM2Aの活性をコントロールする環境因子
控制rRNA转录调节酶KDM2A活性的环境因素
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kato, T., Ueta, M., Miyata, T., Yoshida, H., Maki, Y., Furuike, S., Sakai, A., Wada, A., Namba, K., Mizuuchi Kiyoshi (Yong-Woon Han), 田中祐司]
通讯作者:
田中祐司
rRNA 転写抑制に関わる脱メチル化酵素KDM2A と環境因子
去甲基化酶 KDM2A 和参与 rRNA 转录抑制的环境因素
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[田中祐司, 岡本健吾, 常岡 誠]
通讯作者:
常岡 誠
rRNA転写抑制に関わる脱メチル化酵素KDM2Aと環境因子
去甲基化酶 KDM2A 和参与 rRNA 转录抑制的环境因素
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[田中祐司, 岡本健吾, 常岡誠(田中祐司)]
通讯作者:
常岡誠(田中祐司)
飢餓によるリボソーム RNA 転写抑制のエピゲノム解析
饥饿诱导的核糖体 RNA 转录抑制的表观基因组分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[田中祐司, 岡本健吾, 常岡 誠]
通讯作者:
常岡 誠
飢餓によるリボソームRNA 転写抑制のエピゲノム解析
饥饿引起的核糖体 RNA 转录抑制的表观基因组分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[川本 晃大, 加藤 貴之, Kelly Hughes, 難波 啓一, 田中祐司]
通讯作者:
田中祐司
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