Elucidation of cell position-dependent Hippo-pathway regulatorymechanisms in preimplantation embryos

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Hippo signaling in preimplantation embryos exhibits a cellposition-dependent difference in strength. Inner and outer cells show strong and weaksignaling, respectively. This research clarified the mechanisms of the Hippo pathwayactivation by an adhesion-associated protein Angiomotin and its suppression by cellpolarity. This is the machinery which converts cell position into differential strengthof Hippo signaling. This research uncovered a key problem of the Hippo pathway regulation,which contributes to the progress of the relevant fields