Effets of diallyl trisulfide derived from garlic on fatty liver model of mice.

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Nonalcoholic steatohepatitis (NASH) is liver inflammation of fat and fibrous tissue in the liver that progresses to liver cirrhosis. In this study, the effect of diallyl trisulfide (DATS), one of the garlic flavor components, on NASH model was investigated. At first, the effect of DATS on fatty liver induced by methionine-choline-deficient diet in mice was investigated. DATS treatment reduced the hepatic fat droplets and hepatic triglyceride content. DATS slightly suppressed the levels of AST and ALT in plasma. Second, the effect of DATS on fatty liver using another NASH model, STAM mice was investigated. Although DATS slightly suppressed the plasma TG concentration, no other prominent improvements of hepatic condition were found in this experiment. In conclusion, DATS partially suppressed the TG accumulation in fatty liver in experimental mice model, but the protective effect against the steatosis was weak in this experiment.