Analysis of a novel signaling network that regulates cell growth and division

调节细胞生长和分裂的新型信号网络的分析

• 批准号: 23790331
• 负责人: ADACHI Makoto
• 金额: $ 2.75万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790331/
• 关键词: 細胞内シグナル伝達; 細胞質分裂; 細胞増殖; X線結晶構造解析; 遺伝子発現制御; 癌

We have previously shown that IQGAP3, an intracellular signaling molecule, is responsible for cell proliferation because of its ability to regulate Ras, a proto-oncogene product. In the present study, we showed that IQGAP3 is directly involved in the process of cytokinesis as well, and the underlying molecular mechanisms were also addressed. In addition, expression of the IQGAP3 gene, which is tightly co-related with the state of cell proliferation, as well as the molecular mechanismswith which IQGAP3 regulates Ras, was also investigated.

我们以前已经表明，IQGAP 3，一种细胞内信号分子，是负责细胞增殖，因为它能够调节Ras，一种原癌基因产物。在本研究中，我们发现IQGAP 3也直接参与胞质分裂过程，并讨论了潜在的分子机制。此外，还研究了与细胞增殖状态密切相关的IQGAP 3基因的表达，以及IQGAP 3调节Ras的分子机制。

项目成果

Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.

• DOI: 10.1016/j.cub.2013.05.014
• 发表时间: 2013-07-08
• 期刊: CURRENT BIOLOGY
• 影响因子: 9.2
• 作者: Hirate, Yoshikazu;Hirahara, Shino;Inoue, Ken-ichi;Suzuki, Atsushi;Alarcon, Vernadeth B.;Akimoto, Kazunori;Hirai, Takaaki;Hara, Takeshi;Adachi, Makoto;Chida, Kazuhiro;Ohno, Shigeo;Marikawa, Yusuke;Nakao, Kazuki;Shimono, Akihiko;Sasaki, Hiroshi
• 通讯作者: Sasaki, Hiroshi