Analysis of a novel signaling network that regulates cell growth and division

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We have previously shown that IQGAP3, an intracellular signaling molecule, is responsible for cell proliferation because of its ability to regulate Ras, a proto-oncogene product. In the present study, we showed that IQGAP3 is directly involved in the process of cytokinesis as well, and the underlying molecular mechanisms were also addressed. In addition, expression of the IQGAP3 gene, which is tightly co-related with the state of cell proliferation, as well as the molecular mechanismswith which IQGAP3 regulates Ras, was also investigated.