Comprehensive analysis of the changesin role of cardiac progenitor cells during aging

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Aims of this study are to clarify the changes in role of cardiac progenitor cells (CPCs) during aging and to improve cardiogenic potential of those CPCs. We found that CPCs from human infant heart already became senescent when compared to those from neonates. This fact indicates CPCs possess potential of progenitor cells, not stem cells. Then we also found that CPCs from neonates had higher cardiogenic activity and CPCs from infants had higher angiogenic activity. DNA microarray analysis revealed that down regulation of insulin-like growth factor-1 receptor lead CPCs to have cardiogenic to angiogenic potential. Our results suggest a functional significance of IGF1R-mediated physiological alteration of human CPC differentiation potential.