The inhibitory role of incretin mimetics against lung injury-induced by Toll-like receptor-mediated signaling.
The inhibitory role of incretin mimetics against lung injury-induced by Toll-like receptor-mediated signaling.
肠促胰素模拟物对 Toll 样受体介导的信号传导诱导的肺损伤的抑制作用。
批准号：
23790924
负责人：
NUMATA Takanori
金额：
$2.16万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
中文摘要
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英文摘要
Glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide(GIP) are known incretin hormones. To elucidate the potential role of incretins in prevention of lung injury, we analyzed the expression of incretin receptors and effect of exendin-4, a GLP-1 receptor agonist. Although neither expression of incretin receptors nor effect of exendin-4 was demonstrated in cell culturing models, type II pneumocytes in lung tissue expressed GLP-1 receptor. GLP-1 receptor expression in type II pneumocyte was especially increased in idiopathic pulmonary fibrosis (IPF), suggesting the potential involvement of incretin in IPF pathogenesis.
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DOI：
10.1186/1465-9921-14-30
发表时间：
2013-03-05
期刊：
Respiratory research
影响因子：
5.8
作者：
[Kojima J, Araya J, Hara H, Ito S, Takasaka N, Kobayashi K, Fujii S, Tsurushige C, Numata T, Ishikawa T, Shimizu K, Kawaishi M, Saito K, Kamiya N, Hirano J, Odaka M, Morikawa T, Hano H, Arai S, Miyazaki T, Kaneko Y, Nakayama K, Kuwano K]
通讯作者：
Kuwano K
DOI：
10.4161/onci.20297
发表时间：
2012-08-01
期刊：
Oncoimmunology
影响因子：
7.2
作者：
[Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura S, Nakayama K, Kuwano K]
通讯作者：
Kuwano K
the role of endoplasmic reticulum selective autophagy in the pathogenesis of idiopathic pulmonary fibrosis
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批准号：20K08528
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$2.83万
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财政年份：2020
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负责人：NUMATA Takanori
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依托单位：
海外基金
