Analysis of Teneurin-4 Function in the CNS Myelination

Teneurin-4 在中枢神经系统髓鞘形成中的功能分析

• 批准号: 23790979
• 负责人: SUZUKI Nobuharu
• 金额: $ 2.66万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790979/
• 关键词: 神経分子病態学; 髄鞘; オリゴデンドロサイト; 中枢神経系; 髄鞘関連疾患

In this study, we focused on function of the transmembrane protein teneurin-4 (Ten-4). In the Ten-4 deficient mice, hypomyelination of small-diameter axons was observed. The process formation of Ten-4 deficient oligodendrocytes was significantly reduced. Further, focal adhesion kinase (FAK) played a role downstream of Ten-4 in the process formation. This study will facilitate a better understanding of oligodendrocyte biology and be useful for application studies for the myelin-related diseases.

本研究对跨膜蛋白Teneurin-4（Teneurin-4）的功能进行了研究。在Ten-4缺陷小鼠中，观察到小直径轴突的髓鞘形成不足。Ten-4缺陷少突胶质细胞的突起形成显著减少。此外，粘着斑激酶（FAK）发挥作用的下游十-4的过程形成。本研究将有助于更好地了解少突胶质细胞的生物学特性，并有助于髓鞘相关疾病的应用研究。

项目成果

Oligodendrocyte Development and Dysmyelinating Diseases: Teneurin-4 As a Novel Regulator of CNS Myelination

少突胶质细胞发育和髓鞘形成障碍疾病：Teneurin-4 作为中枢神经系统髓鞘形成的新型调节剂

• 发表时间: 2011
• 作者: 鈴木喜晴;有川-平澤恵理;山田吉彦;赤澤智宏
• 通讯作者: 赤澤智宏

Teneurin-4 Is a Novel Regulator of Chondrogenesis

Teneurin-4 是软骨形成的新型调节剂

• 作者: Baba T;Takeda A;Kikuchi A;Hishio Y;Hosokai Y;Hirayama K;Hasegawa T;Sugeno N;Suzuki K;et al;Nobuharu Suzuki
• 通讯作者: Nobuharu Suzuki