Innate immunity involved in the onset of Henoch-Schoenlein purpura and nephritis

我们推测先天免疫可能参与了过敏性紫癜（HSP）的发病，特别是被称为NF-κB活化抑制剂的A20表达的变化可能是继发性肾炎和HSP加重的重要因素。在本研究中，我们通过定量RT-PCR和淋巴细胞表面表达的流式细胞术分析了A20对HSP的作用。结果显示，LPS刺激后HSP患者的定量RT-PCR和PBMNCs的A20表达与正常对照存在差异，但合并肾炎的HSP患者与未合并肾炎的HSP患者之间无显著差异。另一方面，在肾炎的危险因素中，男性和腹痛患者A20的定量RT-PCR高表达，这可能暗示A20的表达变化可能影响HSP患者肾炎的发生。

We hypothesize that innate immunity may be involved in the onset of Henoch-Schoenlein purpura(HSP), and especially the variation of A20 expression, which is known as an inhibitor of NF-κB activation, can be the important factor for secondary nephritis and the aggravation of HSP. In this study, we analyzed the role of A20 for HSP by quantitative RT-PCR and flow cytometry of lymphocyte surface expression. The results demonstrated the differences between HSP patients and normal controls in A20 of the quantitative RT-PCR and PBMNCs expression after the stimulation of LPS, but no significant difference between HSP patients with and without nephritis. On the other hand, among the risk factors for nephritis, male and the patients with abdominal pain had high expression of quantitative RT-PCR of A20, which may imply that the variation of A20 expression may affect the onset of nephritis in HSP patients.