Identification of host cell factors relating the replication of respiratory syncytial virus

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Respiratory syncytial virus (RSV) is a major causative agent of respiratory tract infections in children worldwide. Preterm children are at a particularly high risk of developing severe and lethal RSV infections. Because effective vaccines are not available, it is urgently necessary to develop antivirus drugs like oseltamivir for influenzavirus. In this study, we tried to identify host cell factors relating the replication of RSV using low-susceptible cell line, MDCK, and cDNA library derived from susceptible cells. As the results, expression of Ephrin-B2, RARRES2, and CCL2 increased the replication of RSV in MDCK. In future, it is necessary to clarify precise roles of these molecules in the replication of RSV.