Analysis of the role of T cell subsets and the development of novel treatment for bullous pemphigoid

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We analyzed the role of T cell subsets in bullous pemphigoid (BP) by using active BP mouse model and cytokine knockout (KO) mice. We generated active BP mouse model by using IL-12KO mice and IL-4KO mice. BP model mice that received IL-12KO splenocytes showed strong deposition of IgG1 (Th2-type reaction) and BP model mice that received IL-4KO splenocytes showed strong deposition of IgG2 (Th1-type reaction), while the deposition of complement and skin disease were almost same in both models. These results indicate that cytokine KO induce the difference in IgG subclass but fail to induce the difference in the amount of IgG-production, disease severity or complement activation in BP model.