The effects of CCR7 ligands on Th2 chemokine production by mouseLangerhans cells

CCR7配体对小鼠朗格汉斯细胞Th2趋化因子产生的影响

• 批准号: 23791255
• 负责人: FUJITA Hideki
• 金额: $ 2.58万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791255/
• 关键词: 皮膚炎症; 再生学; ランゲルハンス細胞; 皮膚免疫学

CCL19 and CCL21 are chemokines which are pivotal for Langerhans cells in their migration form the skin to the draining lymph nodes. We found that CCL19 and CCL21 enhance the production of CCL17, which is known to be a Th2-type chemokine, indicating that CCL19 and CCL21 augment the Th2-type immune response mediated by LCs through the recruitment of Th2 cells. Considering the critical roles of LCs in the pathophysiology of inflammatory skin diseases including atopic dermatitis, our results may provide new insights into the chemokine-targeted therapies for such diseases.

CCL19和CCL21是趋化因子，其在朗格汉斯细胞从皮肤迁移到引流淋巴结中是关键的。我们发现CCL19和CCL21增强了CCL17的产生，CCL17已知是Th2型趋化因子，表明CCL19和CCL21通过募集Th2细胞来增强LC介导的Th2型免疫应答。考虑到LC在炎症性皮肤病（包括特应性皮炎）的病理生理学中的关键作用，我们的研究结果可能为此类疾病的趋化因子靶向治疗提供新的见解。