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The effects of CCR7 ligands on Th2 chemokine production by mouseLangerhans cells

The effects of CCR7 ligands on Th2 chemokine production by mouseLangerhans cells
CCR7配体对小鼠朗格汉斯细胞Th2趋化因子产生的影响
批准号：
23791255
负责人：
FUJITA Hideki
金额：
$2.58万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791255/
关键词：
皮膚炎症再生学ランゲルハンス細胞皮膚免疫学

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英文摘要
CCL19 and CCL21 are chemokines which are pivotal for Langerhans cells in their migration form the skin to the draining lymph nodes. We found that CCL19 and CCL21 enhance the production of CCL17, which is known to be a Th2-type chemokine, indicating that CCL19 and CCL21 augment the Th2-type immune response mediated by LCs through the recruitment of Th2 cells. Considering the critical roles of LCs in the pathophysiology of inflammatory skin diseases including atopic dermatitis, our results may provide new insights into the chemokine-targeted therapies for such diseases.
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