SSRI administration during adolescent period and suicide risk-serotonin receptors and impulsivity

在本研究中，我们试图确定青少年时期服用血清素再摄取抑制剂（SSRI）导致自杀风险增加的原因，重点关注血清素受体功能障碍和SSRI诱导的冲动。我们成功地开发了一个行为任务来评估青春期大鼠的冲动。5-HT2C受体拮抗剂和SSRI联合使用可增强冲动性。然而，在5-HT2C受体敲除小鼠中，SSRI未改变冲动性，与上述大鼠研究不一致。因此，我们无法得出明确的结论。

In the present study, we attempted to determine a cause of increased suicide risk due to serotonin reuptake inhibitor (SSRI) administration at adolescent period, focusing on the dysfunction of serotonin receptors and SSRI-induced impulsivity. We successfully developed a behavioral task to assess impulsivity in adolescent rats. The co-administration of a 5-HT2C receptor antagonist and SSRI enhanced impulsivity. However SSRI administration unaltered impulsivity in 5-HT2C receptor knockout mice, inconsistent with above rat study. Thus we were not able to obtain a clear conclusion.