Fabrication of regularly aligned magnetic nanoparticle by combination of thin-film-growth technique and crystallization of protein

金属以一个原子单位构成晶体。特别是在薄膜中，原子可以以外延的方式排列在下面的层上。另一方面，蛋白质也构建了一个以一个蛋白质为单位的晶体笼结构。在本研究中，我们将外延生长的概念应用到蛋白质晶体中，研究了蛋白质晶体生长的控制。特别地，我们使用了内部有核心的发热焦球菌病毒样颗粒（PfV），并研究了PfV内部磁性纳米颗粒的合成以及应用上述晶体生长概念使磁性纳米颗粒规则排列的可能性。

Metal constructs a crystal with a unit of atom. Especially in the thin film, the atoms can align in an epitaxial manner on the underlying layer. On the other hand, protein also constructs a crystal with a unit of one protein cage structure. In this study, we investigated the control of crystal growth of protein by applying concept of the epitaxial growth to the protein crystal. In particular, Pyrococcus furiosus virus-like particle (PfV) which has a core insid was used and we investigated the synthesis of the magnetic nanoparticle inside the PfV and the possibility of the regular alignment of magnetic nanoparticles by applying the above concept of crystal growth.