Role of host proton-sensing receptors in tumorigenesis: analysis with receptor-deficient mice

众所周知，肿瘤的发生伴随着细胞外酸化。然而，酸化的作用仍然未知。在这里，我们通过受体缺陷小鼠研究了最近发现的质子感应受体的作用。我们的研究结果表明，质子感应受体参与了肿瘤的发生，细胞外酸化改变了M1-M2巨噬细胞的表型。

It is well known that tumorigenesis is accompanied by extracellular acidification. However, the role of acidification remains unknown. Here, we investigated the role of recently identified proton-sensing receptors by using their receptor-deficient mice. Our results suggested that proton-sensing receptors are involved in tumorigenesis andextracellular acidification changes the M1-M2 macrophage phenotype.