The brain regeneration using chemotactic stimulation with favorable chemoattractant factor for autologous tissue stem cells

利用有利的趋化因子对自体组织干细胞进行趋化刺激进行脑再生

• 批准号: 23659164
• 负责人: ITO Takahiko
• 金额: $ 1.75万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659164/
• 关键词: 再生医学; 走化因子; 遊走能; 再生医療

The aim of this project is for regeneration of brain tissue using stem cell migration from undamaged tissue to damaged tissue,that has been implanted high affinity scaffold. We made chemoattractant cocktail for stem cell migration. We confirmed that the cocktail accelerated stem cells migration. And we fabricated nano particles, which can release chemotactic factor long lasting, over 42 days. Finally, we fabricated scaffold. Although the scaffold had appropriate pore size for cell adhesion and growing, scaffold materials had cytotoxicity against stem cells. Cytotoxicity has been improving.

该项目的目的是利用干细胞从未受损组织迁移到已植入高亲和力支架的受损组织来再生脑组织。我们为干细胞迁移制造了化学引诱剂鸡尾酒。我们证实了鸡尾酒加速了干细胞的迁移。我们制备了纳米颗粒，可以持续释放趋化因子，超过42天。最后制作支架。虽然支架具有适合细胞粘附和生长的孔径，但支架材料对干细胞具有细胞毒性。细胞毒性一直在改善。

项目成果

The protective effect of propofol against exposure to anandamide in endothelial cells

异丙酚对内皮细胞暴露于 anandamide 的保护作用

• 发表时间: 2012
• 作者: Naito H;Yoshimura M;Mizuno T;Takasawa S;Tojo T;Taniguchi S.;樋口 京一;YASUNORI MISHIMA
• 通讯作者: YASUNORI MISHIMA