c-Src and braindysfunction: Analysis of ethanol-related behaviors with novel Src knock-in mice

点击翻译按钮获取中文摘要

c-Src is thought to be an important molecule involved in regulation of neural activities in brain. To clarify the role of c-Src, we have established novel knock-in mice carrying a point mutation at Ser75, which is phosphorylated in neurons. We investigated the role of Ser75 phospohrylation in ethanol appetitive behaviors using the novel mutant mouse model. The mutant mice consumed and preferred ethanol less than wild-type mice significantly. These results suggest that c-Src may play a role for ethanol appetitive behaviors and as a possible therapeutic drug target,and give a hint for abstinence development.