Development of new control methods for Serratia infections using the lytic enzyme of bacteriophage

多药耐药性的发展使抗生素治疗粘质沙雷氏菌感染变得困难。我们研究了一种可能的控制方法S。使用噬菌体（噬菌体）的溶解酶的marscecens感染。 对我们分离的两株沙雷氏菌KSP90和KSP100的全基因组序列进行了分析。然而，没有指定具有裂解酶结构域的基因。或者，将噬菌体ETA的裂解酶与芽孢杆菌属噬菌体裂解酶的可能的外膜穿透结构域融合。融合蛋白对沙门氏菌的溶菌活性测定。marscecens先进。

Development of multidrug-resistance makes medical treatment to Serratia marscecens infections by antibiotics difficult. We examined a possible control method to S. marscecens infections using the lytic enzyme of bacteriophage (phage). The complete genome sequences of two Serratia phages KSP90 and KSP100, isolated by us, were analyzed. The genes with lytic enzyme domains, however, were not specified. Alternatively, the lytic enzyme of phage ETA was fused with the possible outer membrane penetration domain of the Bacillus phage lytic enzyme. Examination of bacteriolytic activity of the fused protein to S. marscecens is advanced.