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Prevention of neuropsychiatric functional disease

Prevention of neuropsychiatric functional disease
神经精神功能性疾病的预防
批准号:
23659564
负责人:
OKADA Motohiro
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

项目摘要

项目成果

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中文摘要
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英文摘要
To explore the pathogenesis of autosomal dominant nocturnal frontal lobe epilepsy and to develop novel antiepileptic drug, the present study develop the S286L transgenic rats. The validations of S286L transgenic rats were demonstrated by several examinations. However, after onset epilepsy in S286L transgenic rat, prevention of expression of S286L mutant Chrna4 could not affect the phenotypes of S284L transgenic rats.
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会议论文
DOI: --
发表时间: 2011
期刊: Neuropharmacology
影响因子: 4.7
作者: [Yamamura S, et al]
通讯作者: et al
ILAE Lecture: Varidation criteria for genetic animal models of epilepsy
ILAE 讲座:癫痫遗传动物模型的变异标准
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Ohoyama K, Okada M., Okada M, Okada M, Okada M]
通讯作者: Okada M
Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype.
磷脂酶 C 相关但催化失活的蛋白 1 敲除小鼠中突触外 GABA 能传递功能障碍与癫痫表型相关。
DOI: --
发表时间: 2012
期刊: J Pharmacol Exp Ther
影响因子: 3.5
作者: [Zhu G, Yoshida S, Migita K, Yamada J, Mori F, Tomiyama M, Wakabayashi K, Kanematsu T, Hirata M, Kaneko S, Ueno S, Okada M]
通讯作者: Okada M
Novel Treatment of Epilepsy
癫痫的新疗法
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Okada, M. and Kaneko, S.]
通讯作者: S.
28
    Exploring the development of functional disorders in central nervous system
    • 批准号:
      22390224
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.9万
    • 财政年份:
      2010
    • 负责人:
      OKADA Motohiro
    • 依托单位:
    Generation of epilepsy model animal bearing a genetic abnormality identified in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) of human
    海外基金