Prevention of neuropsychiatric functional disease

神经精神功能性疾病的预防

• 批准号: 23659564
• 负责人: OKADA Motohiro
• 金额: $ 2.33万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659564/
• 关键词: 精神薬理学; 機能性疾患; 情報伝達

To explore the pathogenesis of autosomal dominant nocturnal frontal lobe epilepsy and to develop novel antiepileptic drug, the present study develop the S286L transgenic rats. The validations of S286L transgenic rats were demonstrated by several examinations. However, after onset epilepsy in S286L transgenic rat, prevention of expression of S286L mutant Chrna4 could not affect the phenotypes of S284L transgenic rats.

为探讨常染色体显性遗传夜间额叶癫痫的发病机制，研制新型抗癫痫药物，本研究建立了S286L转基因大鼠模型。S286L转基因大鼠的有效性得到了验证。然而，S286L转基因大鼠癫痫发作后，阻止S286L突变Chrna 4的表达不能影响S284L转基因大鼠的表型。

项目成果

Different actions for acute and chronic administration of mirtazapine on serotonergic transmission associated with raphe nuclei and their innervation cortical regions

米氮平急性和慢性给药对中缝核及其神经支配皮质区相关血清素传递的不同作用

• 发表时间: 2011
• 期刊: Neuropharmacology
• 影响因子: 4.7
• 作者: Yamamura S;et al
• 通讯作者: et al

ILAE Lecture: Varidation criteria for genetic animal models of epilepsy

ILAE 讲座：癫痫遗传动物模型的变异标准

• 发表时间: 2012
• 作者: Ohoyama K;Okada M.;Okada M;Okada M;Okada M
• 通讯作者: Okada M

Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype.

磷脂酶 C 相关但催化失活的蛋白 1 敲除小鼠中突触外 GABA 能传递功能障碍与癫痫表型相关。

• 发表时间: 2012
• 期刊: J Pharmacol Exp Ther
• 影响因子: 3.5
• 作者: Zhu G;Yoshida S;Migita K;Yamada J;Mori F;Tomiyama M;Wakabayashi K;Kanematsu T;Hirata M;Kaneko S;Ueno S;Okada M
• 通讯作者: Okada M

Novel Treatment of Epilepsy

癫痫的新疗法

• 发表时间: 2011
• 作者: Okada;M. and Kaneko;S.
• 通讯作者: S.

Epilepsy genes and beyond

癫痫基因及其他

• 发表时间: 2012
• 作者: Ohoyama K;Okada M.;Okada M;Okada M
• 通讯作者: Okada M