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Development of a novel chelating agent suitable for the prelabeling to establish a generic method for preparation of radiolabeled antibodies.

Development of a novel chelating agent suitable for the prelabeling to establish a generic method for preparation of radiolabeled antibodies.
开发适合预标记的新型螯合剂，建立放射性标记抗体制备的通用方法。
批准号：
23659578
负责人：
HANAOKA Hirofumi
金额：
$2.33万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659578/
关键词：
抗体放射性同位元素有機化学

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中文摘要
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英文摘要
We planned to develop a novel chelating agent suitable for the prelabeling to establish a generic method for preparation radiolabeled antibodies. CHX-DTPA was selected as a chelate group, and then CHX-DTPA-Bn-Gly, which conjugated Gly via benzene ring attached to backbone carbon, was designed and synthesized. The chelating agent could be radiolabeled with indium-111 at low concentration, and it showed rapid urinary excretion. These results indicated that CHX-DTPA-Bn-Gly is a promising mother compound of the novel chelating agent.
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会议论文
優れた尿排泄性を有する111In標識馬尿酸誘導体の合成と基礎的評価
具有优异尿排泄性能的111In标记马尿酸衍生物的合成及基础评价
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [山下篤, 趙芫, 趙松吉, 松浦祐之介, 川井恵一, 玉木長良, 久下裕司, 浅田祐士郎, Yamashita A, 山下　篤, 鈴木博元,金井彩香,上原知也,花岡宏史,荒野泰]
通讯作者： 鈴木博元,金井彩香,上原知也,花岡宏史,荒野泰
Development of a versatile alpha particle therapy using At-211 labeled amino acids with controlled pharmacokinetics
Development of Br-76-labeled amino acid derivatives for imaging tumors
Mechanism elucidation of the lethaleffect of radiolabeled antibody to solid tumor, and searching the factor enhanced this effect
  • 批准号：
    19790855
  • 项目类别：
    Grant-in-Aid for Young Scientists (B)
  • 资助金额：
    $2.31万
  • 财政年份：
    2007
  • 负责人：
    HANAOKA Hirofumi
  • 依托单位：
    Gunma University
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