Challenges to identify endogenous factors associating with cardiac regeneration in heart failure.

点击翻译按钮获取中文摘要

In clinical scenes, patients with severe heart failure show poor prognosis in spite of the capacity. Here, we investigate to identify factors associating with self-regeneration of adult heart using an assist heart mouse model. The left anterior descending coronary artery was ligated to make an acute myocardial infarction in mouse heart (C57BL/6), and then infarcted heart was transplanted into abdomen of recipient mouse. In this model, weight of ventricle was significantly increased and showed longer retention of transplanted cells in unloading group. Our results demonstrate effects of cardiac mechanical stress on not only self-regeneration capacity but also efficacy of cell transplantation into heart and are useful to establish novel therapeutic approach for cardiac regeneration.