Synkinetic movement of the vocal fold in unilaterally paralyzed larynx

单侧喉麻痹声带的联动运动

• 批准号: 23659798
• 负责人: YUMOTO Eiji
• 金额: $ 2.25万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659798/
• 关键词: 反回神経; 過誤神経支配; 共同運動; 喉頭麻痺; 脳・神経

Two animal groups were made: denervation (DNV) and reinnervation (Suture) groups. DNV animals did not show vocal fold movement. Some of Suture group animals showed synkinesis and others in the group showed weak physiological movement during respiration. Greater electromyographic recruitment of TA than PCA was seen during inhalation in the former, while recruitment of PCA was greater than TA during inhalation in majority of the latter subgroup.Aberrant regeneration of nerve fibers in Suture group may have occurred, resulting in synkinesis of the VF depending on the degree of misdirection. Appearance of myosin heavy chain type IIA was not associated with the presence of synkinesis. Administration of Ca channel inhibitor, which facilitates axonal extension during regeneration, in Suture group did not result in decrease of synkinesis.

分为两组动物：去神经（DNV）和再神经（缝合）组。DNV动物没有表现出声带运动。缝线组的一些动物显示出联带运动，该组中的其他动物在呼吸过程中显示出微弱的生理运动。前者在吸气过程中TA的肌电募集大于PCA，而后者大多数亚组在吸气过程中PCA的募集大于TA。缝线组可能发生了神经纤维的异常再生，导致VF的联带运动，取决于错误方向的程度。肌球蛋白重链IIA型的出现与联带运动的存在无关。在缝线组中给予钙通道抑制剂（其在再生过程中促进轴突延伸）并未导致联带运动减少。

项目成果

喉頭筋電図を用いた神経過誤支配の検討

使用喉肌电图检查神经功能障碍

• 发表时间: 2013
• 作者: Morimoto Takeshi;Kanda Hiroyuki;Miyoshi Tomomitsu;LohmannT.K.FujikadoTakashi;讃岐徹治
• 通讯作者: 讃岐徹治

喉頭筋電図による一側喉頭麻痺に対する神経再建術の術前後評価.

使用喉肌电图评估单侧喉麻痹神经重建的术前和术后。

• 发表时间: 2012
• 作者: 本間明宏;他;讃岐徹治
• 通讯作者: 讃岐徹治

Over-adduction of the unaffected vocal fold during phonation in the unilaterally paralyzed larynx.

单侧麻痹的喉部发声时未受影响的声带过度内收。

• DOI: 10.3109/00016489.2014.886020
• 发表时间: 2014
• 期刊: Acta Otolaryngologica
• 作者: Yumoto E;Sanuki T;Minoda R;Kumai Y;Nishimoto K;Kodama N
• 通讯作者: Kodama N

Animal Model for RecurrentLaryngeal Nerve Synkinetic Reinnervationwith Immobile Vocal Fold Using SiliconTube

使用硅管固定声带进行喉返神经联动再神经支配的动物模型

• 发表时间: 2012
• 作者: 山岸麗子;相原一;新家眞;坪田一男;Kumai Y
• 通讯作者: Kumai Y

Electromyography findings in nerve-muscle pedicle implantation with arytenoid adduction for unilateral vocal fold paralysis

神经肌肉蒂植入杓状腱内收治疗单侧声带麻痹的肌电图表现

• 发表时间: 2013
• 作者: 穂積健太;遠藤高生;広田雅和;神田寛行;森本壮;不二門尚;西田幸二;Sanuki T
• 通讯作者: Sanuki T