Basic and clinical research for surgical treatment of unilaterallaryngeal paralysis aiming at reinnervation of the laryngeal muscle

喉肌神经支配手术治疗单侧喉麻痹的基础与临床研究

• 批准号: 22390316
• 负责人: YUMOTO Eiji
• 金额: $ 10.57万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390316/
• 关键词: 脳・神経; 喉頭麻痺; 反回神経; 神経再支配; 神経筋弁

The nerve-muscle pedicle (NMP) flap implantation immediately aftertransection of the recurrent laryngeal nerve facilitated reinnervation of the denervatedthyroarytenoid muscle. Further, NMP implantation was effective in the recovery fromatrophic changes in long-term denervated thyroarytenoid muscle. The authors performedarytenoid adduction in 10 patients and NMP flap implantation combined with arytenoidadduction in 32 patients during research period. The latter patient group showedtime-dependent improvement of vocal function and most of them retrieved their own voicesbefore the onset of laryngeal paralysis.

喉返神经断裂后立即植入神经肌蒂（NMP）皮瓣，有利于失神经的甲状腺样肌的再神经支配。此外，NMP植入对长期失神经甲状腺样肌营养改变的恢复是有效的。作者在研究期间对10例患者行类蝶关节内收，32例患者行NMP皮瓣植入联合类蝶关节内收。后一组患者的声带功能表现出时间依赖性的改善，大多数患者在喉麻痹发作前恢复了自己的声音。

项目成果

Animal Model for RecurrentLaryngeal Nerve Synkinetic Reinnervationwith Immobile Vocal Fold Using SiliconTube

使用硅管固定声带进行喉返神经联动再神经支配的动物模型

• 发表时间: 2012
• 作者: 山岸麗子;相原一;新家眞;坪田一男;Kumai Y
• 通讯作者: Kumai Y

Subjective and Objective Voice Outcomes Following Arytenoid Adducation Plus Nerve-Muscle Pedicle Transfer Compared with Simple Vocal Fold

杓状腱内收加神经肌肉蒂移植后的主观和客观声音结果与简单声带的比较

• 发表时间: 2010
• 作者: Hayashi K;Ohno-Matsui K;Moriyama M;Shimada N;Hayashi W;Tokoro T;Mochizuki M;Mohammed M
• 通讯作者: Mohammed M

Videolaryngoscopic assessment of laryngeal edema after arytenoid adduction

视频喉镜评估杓状软骨内收后喉头水肿

• DOI: 10.1002/lary.23241
• 发表时间: 2012
• 期刊: Laryngoscope
• 影响因子: 2.6
• 作者: 今泉光雅;大森孝一;他;Narajos N
• 通讯作者: Narajos N

披裂軟骨内転術後の咽喉頭腫脹

杓状软骨内收后咽喉肿胀

• 发表时间: 2010
• 期刊: 音声言語医学
• 作者: 東家 完;湯本英二;讃岐徹治;熊井良彦;西本康兵
• 通讯作者: 西本康兵

Effects of Nerve-Muscle Pedicle on Immobile Rat Vocal Folds in the Presence of Partial Innervation

• DOI: 10.1177/000348941011901206
• 发表时间: 2010-12
• 期刊: Annals of Otology, Rhinology & Laryngology
• 作者: T. Aoyama;Y. Kumai;E. Yumoto;Takaaki Ito;Satoru Miyamaru