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Outbreaktal study to development the cytologic therapy to restore the elder persons to be young with milk tooth

开发细胞学疗法使乳牙老人恢复年轻的突破性研究

基本信息

批准号：
23659967
负责人：
NONAKA Kazuaki
金额：
$ 2.41万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2012
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659967/
关键词：
小児歯科学乳歯幹細胞アンチエイジング

项目摘要

We isolated mesenchymal stem cells from human exfoliated deciduous teeth (SHED). SHED owned stem cell properties including clonogenicity, self-renew, stem cell marker expression, multipotency, in vivo tissue regenerative capacity and in vitro immunomodulatory function. To examine the therapeutic efficacy of SHED on immune diseases, SHED were intravenously transplanted into systemic lupus erythematosus (SLE) model MRL/lpr mice. Systemic SHED transplantation improved SLE-like disorders including short lifespan, elevated autoantibody levels and nephritis-like renal dysfunction. SHED transplantation was also able to recover osteoporosis bone reduction in long bones of MRL/lpr mice. Furthermore, SHED -mediated tissue engineering induced bone regeneration in critical calvarial bone-defect sites of immunocompromised mice. These data suggest SHED is source of the stem cell-based immune therapy and tissue engineering in regenerative medicine

我们从人脱落的乳牙(SHIP)中分离出间充质干细胞。SHIP具有干细胞特性，包括克隆形成、自我更新、干细胞标志物表达、多能性、体内组织再生能力和体外免疫调节功能。为探讨SHARE对免疫性疾病的治疗作用，将SHET静脉移植到系统性红斑狼疮(SLE)模型MRL/LPR小鼠体内。系统移植改善了SLE样疾病，包括寿命短、自身抗体水平升高和肾炎样肾功能障碍。大棚移植还能恢复MRL/LPR小鼠长骨骨质疏松的骨质减少。此外，Share介导的组织工程在免疫受损小鼠关键的颅骨缺损处诱导了骨再生。这些数据表明，SHEEP是再生医学中基于干细胞的免疫疗法和组织工程的来源

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients.

蛋白质的不稳定性和功能缺陷是由米勒综合征患者中二氢 - 二氢甲酸脱氢酶突变引起的。

DOI：
10.1042/bsr20120046
发表时间：
2012-12
期刊：
Bioscience reports
影响因子：
4
作者：
Fang J;Uchiumi T;Yagi M;Matsumoto S;Amamoto R;Saito T;Takazaki S;Kanki T;Yamaza H;Nonaka K;Kang D
通讯作者：
Kang D

ウイリアムズ症候群2例の歯科的特徴および臨床的対応

威廉姆斯综合征两例牙齿特征及临床反应