Outbreaktal study to development the cytologic therapy to restore the elder persons to be young with milk tooth

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We isolated mesenchymal stem cells from human exfoliated deciduous teeth (SHED). SHED owned stem cell properties including clonogenicity, self-renew, stem cell marker expression, multipotency, in vivo tissue regenerative capacity and in vitro immunomodulatory function. To examine the therapeutic efficacy of SHED on immune diseases, SHED were intravenously transplanted into systemic lupus erythematosus (SLE) model MRL/lpr mice. Systemic SHED transplantation improved SLE-like disorders including short lifespan, elevated autoantibody levels and nephritis-like renal dysfunction. SHED transplantation was also able to recover osteoporosis bone reduction in long bones of MRL/lpr mice. Furthermore, SHED -mediated tissue engineering induced bone regeneration in critical calvarial bone-defect sites of immunocompromised mice. These data suggest SHED is source of the stem cell-based immune therapy and tissue engineering in regenerative medicine