Fundamental study on physiological properties of polymer-brush-afforded hybrid particles

聚合物刷杂化颗粒生理特性的基础研究

• 批准号: 23685049
• 负责人: OHNO Kohji
• 金额: $ 18.55万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23685049/
• 关键词: リビングラジカル重合; グラフト重合; ポリマーブラシ; 微粒子; 体内動態; 高分子合成; 高分子構造・物性; 生体材料; ナノ材料; 表面・界面物性

Perfectly dispersive polymer-brush-afforded hybrid particles were synthesized by surface-initiated living radical polymerization. The protein adsorption properties and circulation lifetime in the blood of the resultant hybrids particles were significantly dependent on their structural parameters. Some hybrid particles exhibiting an excellently prolonged circulation lifetime preferentially accumulated in tumor tissue. The tumor-targeted delivery was optically visualized using hybrid particles grafted with fluorescence-labeled polymer brushes. In addition, the tumor-targeted delivery of polymer-brush-afforded iron oxide nanoparticles was visualized by an MRI measurement.

通过表面引发活性自由基聚合，合成了具有良好分散性的聚合物-刷状杂化粒子。蛋白质的吸附性能和循环寿命在血液中的杂交粒子显着依赖于它们的结构参数。一些表现出良好的延长循环寿命的杂化颗粒优先在肿瘤组织中积聚。使用接枝有荧光标记的聚合物刷的混合颗粒，对肿瘤靶向递送进行光学可视化。此外，通过MRI测量可视化聚合物刷提供的氧化铁纳米颗粒的肿瘤靶向递送。

项目成果

Materials Designing by High-Pressure Living Radical Polymerization

高压活性自由基聚合材料设计

• DOI: 10.4131/jshpreview.21.4
• 发表时间: 2011
• 期刊: The Review of High Pressure Science and Technology
• 作者: H. Nishihara;T. Kyotani;山下兼一;大野工司
• 通讯作者: 大野工司

Fabrication of Contrast Agents for Magnetic Resonance Imaging from Polymer-Brush-Afforded Iron Oxide Magnetic Nanoparticles Prepared by Surface-Initiated Living Radical Polymerization

• DOI: 10.1021/bm400770n
• 发表时间: 2013-10-01
• 期刊: BIOMACROMOLECULES
• 影响因子: 6.2
• 作者: Ohno, Kohji;Mori, Chizuru;Tabata, Yasuhiko
• 通讯作者: Tabata, Yasuhiko

Bioimaging with Polymer Brush-Decorated Magnetic Nanoparticles Synthesized by Surface-Initiated Living Radical Polymerization

表面引发活性自由基聚合合成的聚合物刷修饰的磁性纳米粒子的生物成像

• 发表时间: 2013
• 作者: K. Ohno;C. Mori;S. Yoshida;Y. Tago
• 通讯作者: Y. Tago

Polymer Brush-Afforded Fine Particles Synthesized by Surface-Initiated Living Radical Polymerization

表面引发活性自由基聚合合成聚合物刷提供的细颗粒

• 发表时间: 2011
• 作者: K. Ohno

Polymer Brush-Afforded Hybrid Particles Synthesized by Surface-Initiated Radical Polymerization

表面引发自由基聚合合成的聚合物刷提供的杂化颗粒

• 发表时间: 2011
• 作者: Yuhei Terada;Tatsuro Endo;Hirokazu Seto;Yu Hoshino;Yoshiko Miura;大野工司
• 通讯作者: 大野工司