Fundamental study on physiological properties of polymer-brush-afforded hybrid particles

通过表面引发活性自由基聚合，合成了具有良好分散性的聚合物-刷状杂化粒子。蛋白质的吸附性能和循环寿命在血液中的杂交粒子显着依赖于它们的结构参数。一些表现出良好的延长循环寿命的杂化颗粒优先在肿瘤组织中积聚。使用接枝有荧光标记的聚合物刷的混合颗粒，对肿瘤靶向递送进行光学可视化。此外，通过MRI测量可视化聚合物刷提供的氧化铁纳米颗粒的肿瘤靶向递送。

Perfectly dispersive polymer-brush-afforded hybrid particles were synthesized by surface-initiated living radical polymerization. The protein adsorption properties and circulation lifetime in the blood of the resultant hybrids particles were significantly dependent on their structural parameters. Some hybrid particles exhibiting an excellently prolonged circulation lifetime preferentially accumulated in tumor tissue. The tumor-targeted delivery was optically visualized using hybrid particles grafted with fluorescence-labeled polymer brushes. In addition, the tumor-targeted delivery of polymer-brush-afforded iron oxide nanoparticles was visualized by an MRI measurement.