Fundamental study on physiological properties of polymer-brush-afforded hybrid particles

采用表面引发活性自由基聚合的方法合成了分散性良好的聚合物-电刷杂化颗粒。所得到的杂交颗粒的蛋白质吸附性能和在血液中的循环寿命显著依赖于它们的结构参数。一些杂交颗粒表现出优异的延长循环寿命，优先在肿瘤组织中积累。肿瘤靶向递送使用荧光标记聚合物刷嫁接的杂交颗粒进行光学可视化。此外，通过MRI测量，聚合物电刷提供的氧化铁纳米颗粒的肿瘤靶向递送被可视化。

Perfectly dispersive polymer-brush-afforded hybrid particles were synthesized by surface-initiated living radical polymerization. The protein adsorption properties and circulation lifetime in the blood of the resultant hybrids particles were significantly dependent on their structural parameters. Some hybrid particles exhibiting an excellently prolonged circulation lifetime preferentially accumulated in tumor tissue. The tumor-targeted delivery was optically visualized using hybrid particles grafted with fluorescence-labeled polymer brushes. In addition, the tumor-targeted delivery of polymer-brush-afforded iron oxide nanoparticles was visualized by an MRI measurement.