Elucidation of the endocrine regulatory mechanism common in vertebrate ovulation.

本研究旨在阐明青鳉排卵的内分泌调节机制。该研究揭示了诱导排卵相关基因的关键转录因子--核内孕酮受体（nPR）的诱导机制。结果表明，nPR参与了MT 2-MMP和派-1的诱导，二者在排卵过程中起重要作用。阐明了nPR配体成熟诱导激素（17 a，20 b-DHP）合成酶的表达模式。基于这些结果，我们提出了一种新的内分泌调节机制模型，用于诱导排卵相关酶在排卵过程中负责卵泡层的降解。

The aim of the present study is to elucidate the endocrine regulatory mechanism of ovulation in the medaka. The study disclosed a mechanism for inducing nuclear progestin receptor (nPR), which was the essential transcription factor for induction of ovulation-associated genes. It was revealed that nPR was involved in the induction of MT2-MMP and PAI-1, both which played an important role on ovulation. An expression pattern of the synthesizing enzymes for a maturation inducing hormone (17a, 20b-DHP), a ligand of nPR, was elucidated. Based on the results, we propose the novel model of the endocrine regulatory mechanism for inducing the ovulation-related enzymes responsible for degradation of follicle layer during ovulation.