Exprolation of regulatory mechanisms of root resorption by immune cells

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1. We established the root resorption model in mice by orthodontic wire. Using the model, we explored the Treg in periodontium in mRNA and protein levels. 2. Treg prified from mouse splenocytes express TACE, that play a role in osteoclastogenic cytokine release. We established the hybridoma that produce monoclonal neutralizing antibody against human TACE, clarified the epitope sequence, and applied for patent. 3. Odontoclast is close lineage cells to osteoclast, and we found and reported that Keap1/Nrf2 axis play a role in the regulation of osteoclastogenesis. 4. We found that Nrf2 activation can attenuate osteoclastogenesis in vitro and in vivo, and applied for patent.