The roles of GABA on development and function of taste bud cells

本研究表明：(1)GABA可能在味蕾或味觉细胞的发育和味觉神经纤维对味蕾的神经支配中没有关键作用；(2)GABA可能从一部分味觉细胞，可能是III型味觉细胞，通过这些细胞的去极化释放出来；(3)味觉细胞内Cl-浓度可能很高，因此GABA会在这些味觉细胞中引起兴奋反应。这些结果提示GABA可能在味蕾的味觉敏感性调节中起一定作用。

This study has demonstrated that (1) GABA may not have a pivotal role in development of taste buds or taste cells and in innervation of gustatory nerve fibers to taste buds, (2) GABA may be released from a subset of taste cells, possibly Type III cells, by depolarization of these cells, (3) intracellular Cl- concentration in taste cells may be very high therefore GABA would induce excitatory responses in these taste cells. These results suggest that GABA may play some roles in modulation of taste sensitivities in taste buds.