Reception, transduction, and modulation of sweet taste in taste receptor cells : Analysis by using transgenic mice.

本研究发现(1)内源性大麻素通过甜味敏感味觉细胞上的CB1受体选择性地增强甜味；(2)表达甜味和鲜味受体成分T1R3的味觉细胞，通过T1R3-绿色荧光蛋白小鼠鉴定，对各种甜味和/或鲜味刺激有反应；(3)缺乏T1R3、Gustducin或Trpm5的T1R3-GFP味觉细胞不对味觉刺激做出反应；(4)T1R3-GFP味觉细胞表达Gα11、14、S、Q和I2为Gα亚单位，而不是Gustducin。

This study has revealed (1) Endocannabinoids selectively enhance sweet taste via CB1 receptor on sweet sensitive taste cells, (2) Taste cells expressing T1R3, a sweet and umami taste receptor component, that are identified by using T1R3-GFP mice respond to various sweet and/or umami taste stimuli, (3) T1R3-GFP taste cells lacking T1R3, gustducin, or TRPM5 do not respond to taste stimuli, (4) T1R3-GFP taste cells express Gα11, 14, s, q, and i2 as Gα subunits other than gustducin.