Molecular and cell biological analyses of mechanism of synaptic plasticity

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Although FGF signaling has been known to induce presynaptic differentiation in mammalian synaptic development, it remains unclear whether FGF signaling has a role in postsynaptic development. Here we report that Drosophila FGF signaling is required for the postsynaptic development of neuromuscular junctions. Two Drosophila FGF ligands, Pyramus and Thisbe, are expressed in neurons and muscles and a FGF receptor, Heartless, is localized in close proximity to postsynaptic GluRIIA clusters. Mutant analyses found that FGF signaling positively regulates G1uRI1A localization on postsynaptic sites. Moreover, GluRIIA expression is also controlled transcriptionally by FGF signaling. These results suggest that Drosophila FGF signaling is a regulator of Glutamate receptor expression in postsynaptic NMJ development.