Activity control of inhibitory interneuron networks by pyramidal cells

锥体细胞抑制性中间神经元网络的活动控制

• 批准号: 23700478
• 负责人: OTSUKA Takeshi
• 金额: $ 2.75万
• 依托单位: National Institute for Physiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700478/
• 关键词: 大脳皮質; 錐体細胞; 介在細胞; FS細胞; ギャップジャンクション; 神経科学

Cortical fast-spiking (FS) interneurons are electrically interconnected through gap junctions and form dendritic net structures extending over different functional columns. Here, I investigated how pyramidal cells regulate FS cell network activity. Using paired recordings and glutamate puff-stimulations, I found that FS cell pairs connected by electrical synapses shared common inputs from surrounding pyramidal cells more frequently than those unconnected or connected only by chemical synapses. Experimental and simulation results suggest that activity spread evoked by common inputs to electrically connected FS cells depends on network state. When cells were in the depolarized state, common inputs to electrically connected cells enhanced spike induction and induced inhibitory effects in surrounding FS cells. By contrast, in the hyperpolarized state, either sub- or supra-threshold inputs produced depolarizing potentials in nearby cells. Our results suggest that globally connected FS cell networks are locally regulated by pyramidal cells in an electrical connection- and network state-dependent manner.

皮质快速加速器（FS）中间神经元通过间隙连接和形成在不同功能柱上延伸的树突净结构进行电互连。在这里，我研究了锥体细胞如何调节FS细胞网络活性。使用配对的记录和谷氨酸吹气刺激，我发现与仅通过化学突触的未连接或连接的FS分子共享来自周围金字塔细胞的共同输入的FS细胞对更频繁。实验和仿真结果表明，通用输入到电连接的FS细胞引起的活性扩散取决于网络状态。当细胞处于去极化状态时，对电连接细胞的共同输入增强了尖峰诱导，并在周围的FS细胞中诱导抑制作用。相比之下，在超极化状态下，亚阈值或上阈值输入在附近的细胞中产生去极化电位。我们的结果表明，全球连接的FS细胞网络以电连接和网络状态依赖性方式在局部受到锥体细胞的局部调节。

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