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Establishment of HIV-1-infected mouse model using HLA-expressedhumanized mice, and the analysis of immune response in the mice.

Establishment of HIV-1-infected mouse model using HLA-expressedhumanized mice, and the analysis of immune response in the mice.
利用HLA表达的人源化小鼠建立HIV-1感染小鼠模型,并分析小鼠的免疫反应。
批准号:
23700513
负责人:
SATO Yoshinori
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
A small animal model for the analysis of HIV -1 infection has notbeen established yet. T o establish the animal model, we generated new humanized miceand investigated the responses of human T cells against HIV -1 in the mice. HIV -1 wasdetected in plasma of the mice after HIV -1 infection and the number of CD4 T cells in themice decreased. Also, effector CD8 T cells which are important for the elimination ofHIV -1-infected cells were induced in the mice after HIV -1 infection. These results indicatethat a humanized mouse model will be available for the analysis of HIV -1 infection
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Analysis ofhuman CD8+T cells in HLA-B*51:01transgenic humanized mice afterinfection with HIV-1.
HIV-1 感染后 HLA-B*51:01 转基因人源化小鼠中人类 CD8 T 细胞的分析。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yoshinori Sato, et al.]
通讯作者: et al.
DOI: 10.1371/journal.pone.0042776
发表时间: 2012
期刊: PloS one
影响因子: 3.7
作者: [Sato Y, Nagata S, Takiguchi M]
通讯作者: Takiguchi M
ヒト化マウスを用いた HIV感染モデルマウスの作製 グローバルCOE プログラム「エイズ制圧を目指した国際教育研究拠点」
使用人源化小鼠制作HIV感染模型小鼠 全球COE项目“旨在消除艾滋病的国际教育和研究中心”
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yoshinori Sato, Sayaka Nagata, Masafumi Takiguchi, 佐藤義則]
通讯作者: 佐藤義則
Analysis of human CD8+ T cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1
HIV-1感染后HLA-B*51:01转基因人源化小鼠中人类CD8 T细胞的分析
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yoshinori Sato, Sayaka Nagata, Masafumi Takiguchi]
通讯作者: Masafumi Takiguchi
14
    Construction of a DNA barcode library for practical insect monitoring in museum
    Search for thermoelectromotive force of thin/bulk interfacial structured film comprised of only single-walled carbon nanotubes
    • 批准号:
      23656419
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2011
    • 负责人:
      SATO Yoshinori
    • 依托单位:
    Development of residual gas ionization beam current monitor for high-intensity DC beams
    Development of anode of high performance lithium ion capacitors using single-walled carbon nanotube thin films
    • 批准号:
      23686092
    • 项目类别:
      Grant-in-Aid for Young Scientists (A)
    • 资助金额:
      $15.06万
    • 财政年份:
      2011
    • 负责人:
      SATO Yoshinori
    • 依托单位:
    海外基金