Establishment of HIV-1-infected mouse model using HLA-expressedhumanized mice, and the analysis of immune response in the mice.
Establishment of HIV-1-infected mouse model using HLA-expressedhumanized mice, and the analysis of immune response in the mice.
批准号:
23700513
负责人:
SATO Yoshinori
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
A small animal model for the analysis of HIV -1 infection has notbeen established yet. T o establish the animal model, we generated new humanized miceand investigated the responses of human T cells against HIV -1 in the mice. HIV -1 wasdetected in plasma of the mice after HIV -1 infection and the number of CD4 T cells in themice decreased. Also, effector CD8 T cells which are important for the elimination ofHIV -1-infected cells were induced in the mice after HIV -1 infection. These results indicatethat a humanized mouse model will be available for the analysis of HIV -1 infection
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Analysis ofhuman CD8+T cells in HLA-B*51:01transgenic humanized mice afterinfection with HIV-1.
HIV-1 感染后 HLA-B*51:01 转基因人源化小鼠中人类 CD8 T 细胞的分析。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yoshinori Sato, et al.]
通讯作者:
et al.
DOI:
10.1371/journal.pone.0042776
发表时间:
2012
期刊:
PloS one
影响因子:
3.7
作者:
[Sato Y, Nagata S, Takiguchi M]
通讯作者:
Takiguchi M
ヒト化マウスを用いた HIV感染モデルマウスの作製 グローバルCOE プログラム「エイズ制圧を目指した国際教育研究拠点」
使用人源化小鼠制作HIV感染模型小鼠 全球COE项目“旨在消除艾滋病的国际教育和研究中心”
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yoshinori Sato, Sayaka Nagata, Masafumi Takiguchi, 佐藤義則]
通讯作者:
佐藤義則
Analysis of human CD8+ T cells in HLA-B*51:01 transgenic humanized mice after infection with HIV-1
HIV-1感染后HLA-B*51:01转基因人源化小鼠中人类CD8 T细胞的分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yoshinori Sato, Sayaka Nagata, Masafumi Takiguchi]
通讯作者:
Masafumi Takiguchi
Elicitationof HIV-1-specific effector CD8+T cellsin HLA-B*51:01 transgenic humanizedmice infected with HIV-1.
在感染 HIV-1 的 HLA-B*51:01 转基因人源化小鼠中诱导 HIV-1 特异性效应 CD8 T 细胞。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[oshinori Sato, et al.]
通讯作者:
et al.
共 14 条
Construction of a DNA barcode library for practical insect monitoring in museum
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批准号:18K01096
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.58万
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财政年份:2018
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负责人:SATO Yoshinori
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依托单位:
Search for thermoelectromotive force of thin/bulk interfacial structured film comprised of only single-walled carbon nanotubes
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批准号:23656419
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2011
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负责人:SATO Yoshinori
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依托单位:
Development of residual gas ionization beam current monitor for high-intensity DC beams
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批准号:23540357
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2011
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负责人:SATO Yoshinori
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依托单位:
Development of anode of high performance lithium ion capacitors using single-walled carbon nanotube thin films
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批准号:23686092
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$15.06万
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财政年份:2011
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负责人:SATO Yoshinori
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依托单位:
Changes in scholarly communication and access to digital information resources.
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批准号:22300084
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.32万
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财政年份:2010
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负责人:SATO Yoshinori
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依托单位:
Elucidation of the ecological significance for nitrous oxide emission by soil fungi
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批准号:21710004
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$3.0万
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财政年份:2009
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负责人:SATO Yoshinori
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依托单位:
Production of hydroxyapatite/carbon nanotube composites with high strength and flexibility
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批准号:21760538
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2009
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负责人:SATO Yoshinori
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依托单位:
Development of Binder-Free Carbon Nanotube Fibers Designed with High Strength and Electric Conductivity
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批准号:19686038
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$11.48万
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财政年份:2007
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负责人:SATO Yoshinori
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依托单位:
X-Ray Crystal Structure Analyses of Inante Immunological TLR-Related Receptor Proteins for Sepsis Treatments
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批准号:17390010
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.2万
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财政年份:2005
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负责人:SATO Yoshinori
-
依托单位:
Gene expressions of Cross-talking of transcription factors controlling development of oral-maxillofacial region
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批准号:14571866
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2002
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负责人:SATO Yoshinori
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依托单位:
Hydrological Research for Lake Acidification
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批准号:11680091
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.09万
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财政年份:1999
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负责人:SATO Yoshinori
-
依托单位:
海外基金