Analysis for crosstalk between estrogen and Wnt signalings

内分泌化学物质（激素）的综合网络调节大多数动物的生殖系统。雌激素是这些内分泌激素中的一类，负责诱导涉及许多器官系统的行为和生理过程。女性生殖道为配子受精、植入和随后的胚胎发育以及胎儿分娩提供场所。女性生殖道中的器官也涉及妇女的健康问题，包括肿瘤的发生。生长因子和ER信号在小鼠生殖器官的细胞增殖、分化和肿瘤进展中发挥重要作用。用己烯雌酚（DES）处理新生小鼠会诱导阴道上皮的雌激素非依赖性持续增殖和角化，这通常会导致生命后期的癌性病变。然而，雌激素依赖性和非依赖性途径的机制基本上仍然未知。我们发现Wnt/β-catenin信号通路参与了小鼠阴道发育暴露于雌激素的雌激素非依赖性现象。

An integrated network of endocrine chemicals (hormones) modulates the reproductive systems in most animals. Estrogens, one class of these endocrine hormones, are responsible for the induction of behavioral and physiological processes involving many organ systems. The female reproductive tract provides the sites for gamete fertilization, implantation and subsequent development of the embryo and delivery of the fetus. Organs in the female reproductive tract are also involved in women’s health issues including and tumorigenesis. Growth factors and ER signaling cooperate to play essential roles in cell proliferation, differentiation and tumor progression in mouse reproductive organs. Treatment of neonatal mice with diethylstilbestrol (DES) induces an estrogen-independent persistent proliferation and cornification of the vaginal epithelium, which typically results in cancerous lesions later in life. However, the mechanisms of the estrogen-dependent and -independent pathways had remained essentially unknown. We found that Wnt/beta-catenin signaling is involved in estrogen-independent phenomena in mouse vagina developmentally exposed to estrogens.。