Analysis for developmental mechanisms of protrusion and outgrowth

突出和生长的发育机制分析

• 批准号: 21770239
• 负责人: MIYAGAWA Shinichi
• 金额: $ 2.91万
• 依托单位: 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設) (2010)National Institutes of Natural Sciences Okazaki Research Facilities (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21770239/
• 关键词: 器官形成; 外生殖器; シグナリングセンター; 成長因子; 生殖器官; 発生; ヘッジホッグ

Embryonic appendicular structures, including the developing external genitalia, are suitable models to analyze the developmental mechanisms of organ protrusion and outgrowth. Although several studies have evaluated individual functions of different growth factors on appendicular growth, the coordinated function of signaling cascades is poorly understood. Our results provide new insights into the integration of growth factor signaling (i.e. hedgehog, Wnt and Fgfs) in the appendicular developmental programs regulating external genitalia development. We also demonstrated the interaction of such growth factors and sex steroid hormones (androgens) during later stage of external genital development.

胚胎附肢结构，包括发育中的外生殖器，是分析器官突出和生长的发育机制的合适模型。尽管一些研究评估了不同生长因子对阑尾生长的个体功能，但信号级联的协调功能仍知之甚少。我们的结果为生长因子信号（即刺猬蛋白、Wnt 和 Fgfs）在调节外生殖器发育的阑尾发育程序中的整合提供了新的见解。我们还证明了这些生长因子和性类固醇激素（雄激素）在外生殖器发育后期的相互作用。

项目成果

Molecular mechanisms of induction of persistent changes by estrogenic chemicals on female reproductive tracts and external genitalia.

雌激素化学物质对女性生殖道和外生殖器诱导持续变化的分子机制。

• 发表时间: 2011
• 期刊: J Steroid Biochem Mol Biol in press
• 作者: Miyagawa S;Sato M;Iguchi T.
• 通讯作者: Iguchi T.

Estrogen receptor a is indispensable for the induction of persistent vaginal change by neonatal 5a-dihydrotestosterone exposure.

雌激素受体 a 对于新生儿接触 5a-二氢睾酮引起的持续性阴道变化是必不可少的。

• 发表时间: 2009
• 作者: Miyagawa S.;Katsu Y.;Iguchi T.
• 通讯作者: Iguchi T.

Genetic integrations of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.

雄激素和 Wnt/β-连环蛋白途径的遗传整合促进外生殖器男性化。

• 发表时间: 2009
• 期刊: Mol Endcrinol. 23
• 作者: Miyagawa S;Satoh Y;Haraguchi R;Suzuki K;Iguchi T;Taketo MM;Nakagata N;Matsumoto T;Takeyama K;Kato S;Yamada G.
• 通讯作者: Yamada G.

外生殖器雄性化過程におけるヘッジホッグシグナルの解析

外生殖器男性化过程中的刺猬信号分析

• 发表时间: 2010
• 作者: 宮川信一;原口竜摩;井口泰泉;山田源
• 通讯作者: 山田源

Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.

• DOI: 10.1371/journal.pone.0016260
• 发表时间: 2011-01-20
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Matsumaru D;Haraguchi R;Miyagawa S;Motoyama J;Nakagata N;Meijlink F;Yamada G
• 通讯作者: Yamada G