Regulation of anti-tumor immunity by targeting cyclooxygenase-2 expressing cells

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The immunosuppression in tumor tissue has been attributed to tumor cells expressing cyclooxygenase (COX) -2. From this study, COX-2 was also expressed in tumor infiltrated CD11c+ cells. It was shown that through the production of immunosuppressive cytokines by COX-2+CD11c+ cells, the cells are largely responsible for immunosuppression in tumor tissues. Moreover, liposome (COX-2 selective inhibitors encapsulated liposome) which newly prepared to target the COX-2+CD11c+ cells, it showed the possibility to improve the immunosuppression by COX-2+CD11c + cells in tumor tissues.