Regulation of anti-tumor immunity by targeting cyclooxygenase-2 expressing cells

通过靶向 cyclooxygenase-2 表达细胞调节抗肿瘤免疫

• 批准号: 23701076
• 负责人: INOUE Joe
• 金额: $ 2.83万
• 依托单位: Kyoto University (2012-2013)Kitasato University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23701076/
• 关键词: cox-2; tumor; dendritic cell; liposome; COX-2

The immunosuppression in tumor tissue has been attributed to tumor cells expressing cyclooxygenase (COX) -2. From this study, COX-2 was also expressed in tumor infiltrated CD11c+ cells. It was shown that through the production of immunosuppressive cytokines by COX-2+CD11c+ cells, the cells are largely responsible for immunosuppression in tumor tissues. Moreover, liposome (COX-2 selective inhibitors encapsulated liposome) which newly prepared to target the COX-2+CD11c+ cells, it showed the possibility to improve the immunosuppression by COX-2+CD11c + cells in tumor tissues.

肿瘤组织的免疫抑制归因于肿瘤细胞表达环氧化酶(COX) -2。在本研究中，COX-2也在肿瘤浸润的CD11c+细胞中表达。研究表明，COX-2+CD11c+细胞通过产生免疫抑制因子，在肿瘤组织中发挥了重要的免疫抑制作用。此外，新制备的针对COX-2+CD11c+细胞的脂质体（COX-2选择性抑制剂包封脂质体）显示出改善肿瘤组织中COX-2+CD11c+细胞免疫抑制的可能性。

项目成果

Liposomal lipopolysaccharide initiates TRIF-dependent signaling pathway independent of CD14.

• DOI: 10.1371/journal.pone.0060078
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Watanabe S;Kumazawa Y;Inoue J
• 通讯作者: Inoue J

Intracellular delivery of lipopolysaccharide induces effective Th1-immune responses independent of IL-12.

• DOI: 10.1371/journal.pone.0068671
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Watanabe S;Inoue J
• 通讯作者: Inoue J