To identify the role of microRNA as a tumor suppressor in hematological malignancy
To identify the role of microRNA as a tumor suppressor in hematological malignancy
批准号:
23701080
负责人:
WATANABE Atsushi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
We analyzed aberrant expression of microRNAs in hematological malignancies. The levels of miR-150 expression in several lymphoma cell lines and clinical samples are significantly lower than in normal NK cells. We also found that miR-150 directly downregulates the expression of DKC1 and AKT2. These results suggest that miR-150 works as a tumor suppressor, and leading to telomerase activation. These findings provide new insight into the pathogenesis of malignant lymphoma.
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The Role of Mir-150 as a Tumor Suppressor In NK/T cell lymphoma
Mir-150 作为肿瘤抑制因子在 NK/T 细胞淋巴瘤中的作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[渡部敦, 田川博之, 澤田賢一]
通讯作者:
澤田賢一
The role of mir -150 as a tumor suppressor in NK/T cell lymphomaた
mir -150作为抑癌基因在NK/T细胞淋巴瘤中的作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Waatanabe A, Tagawa H, Takahashi N, et al., 伊藤貢, 渡部敦,田川博之,手島和暁,奈良美保亀岡吉弘,高橋直人,久米正晃,清水則夫,澤田賢一, 渡部敦,田川博之,澤田賢一]
通讯作者:
渡部敦,田川博之,澤田賢一
The role of mir-150 as Tumor suppressor in malignant lymphoma
mir-150作为肿瘤抑制因子在恶性淋巴瘤中的作用
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Waatanabe A, Tagawa H, Takahashi N, et al., 伊藤貢, 渡部敦,田川博之,手島和暁,奈良美保亀岡吉弘,高橋直人,久米正晃,清水則夫,澤田賢一]
通讯作者:
渡部敦,田川博之,手島和暁,奈良美保亀岡吉弘,高橋直人,久米正晃,清水則夫,澤田賢一
がん抑制的マイクロRNA-150のT細胞リンパ腫における役割
肿瘤抑制性 microRNA-150 在 T 细胞淋巴瘤中的作用
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[渡部敦, 田川博之, 手島和暁, 奈 良美保, 亀岡吉弘, 高橋直人, 久 米正晃, 清水則夫, 澤田賢一, 伊藤 貢]
通讯作者:
伊藤 貢
がん抑制的マイクロRNA-150のT細胞リンパ腫における役割
肿瘤抑制性 microRNA-150 在 T 细胞淋巴瘤中的作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Waatanabe A, Tagawa H, Takahashi N, et al., 伊藤貢]
通讯作者:
伊藤貢
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海外基金