Clarification of mechanism underlying adipocyte differentiation using a novel model for ectopic accumulation of brown fat tissues

使用棕色脂肪组织异位积累的新模型阐明脂肪细胞分化的机制

• 批准号: 24790907
• 负责人: JIANG Meizi
• 金额: $ 2.75万
• 依托单位: Toho University (2013)Chiba University (2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790907/
• 关键词: メタボリックシンドローム; 脂質代謝異常; 脂質代謝異常症; 熱代謝; 糖尿病; インスリン抵抗性; 脂肪分化

Obesity is frequently accompanied with metabolic disorders such as diabetes, dyslipidemia and hypertension. However, the development of accompanied disorders varies largely depending on the genetic factors as well as life-style conditions. Adipose tissues have been largely classified to two types with different histological and physiological properties; white adipose tissue and brown adipose tissue (BAT). Animal studies have shown that the failure in increasing heat production in BAT leads to excess of energy intake compared with energy expenditure. The existence of BAT in adult humans has been recently found using modern imaging techniques. We studied that the role of Lr11 in the production of ectopic differentiation of brown adipocytes in WAT using the knockout mice. The soluble receptor was important for the prevention of the ectopic differentiation of BAT in mice. Our study results contribute to a new treatment development for the obesity-associated diabetes.

肥胖常伴有代谢紊乱，如糖尿病、血脂异常和高血压。然而，伴随疾病的发展在很大程度上取决于遗传因素和生活方式条件。脂肪组织大致分为两类，具有不同的组织学和生理特性；白色脂肪组织和棕色脂肪组织（BAT）。动物研究表明，在BAT中不能增加产热会导致能量摄入多于能量消耗。最近使用现代成像技术发现成人中存在BAT。我们利用敲除小鼠研究了Lr11在WAT褐色脂肪细胞异位分化产生中的作用。可溶性受体对防止小鼠BAT异位分化有重要作用。我们的研究结果为肥胖相关糖尿病的治疗提供了新的思路。

项目成果

SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer's disease

• DOI: 10.1007/s00406-012-0295-x
• 发表时间: 2012-09-01
• 期刊: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
• 影响因子: 4.7
• 作者: Guo, Liang-Hao;Westerteicher, Christine;Perneczky, Robert
• 通讯作者: Perneczky, Robert

Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy

• DOI: 10.1007/s00417-013-2373-9
• 发表时间: 2013-05
• 期刊: Graefe's Archive for Clinical and Experimental Ophthalmology
• 作者: T. Shiba;H. Bujo;Mao Takahashi;Yukihiro Sato;M. Jiang;Y. Hori;T. Maeno;K. Shirai

The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells

LR11 的可溶形式是缺氧诱导、uPAR 介导的未成熟血液细胞粘附的调节剂

• 发表时间: 2013
• 期刊: J Biol Chem
• 影响因子: 4.8
• 作者: Keigo Nishii;Chiaki Nakaseko;Meizi Jiang;Naomi Shimizu;Masahiro Takeuchi;Wolfgang Johann Schneider;and Hideaki Bujo
• 通讯作者: and Hideaki Bujo

Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias

• DOI: 10.1016/j.cca.2012.06.025
• 发表时间: 2012-10-09
• 期刊: CLINICA CHIMICA ACTA
• 影响因子: 5
• 作者: Sakai, Shio;Nakaseko, Chiaki;Bujo, Hideaki
• 通讯作者: Bujo, Hideaki

β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau

β 位点淀粉样前体蛋白裂解酶 1 活性与具有 A 型重复序列的分拣蛋白相关受体、可溶性淀粉样前体蛋白和 tau 蛋白的脑脊液浓度相关

• DOI: 10.1016/j.jalz.2012.01.015
• 发表时间: 2013
• 期刊: Alzheimers Dement
• 影响因子: 14
• 作者: Tsolakidou A;Alexopoulos P;Guo LH;Grimmer T;Westerteicher C;Kratzer M;Jiang M;Bujo H;Roselli F;Leante MR;Livrea P;Kurz A;Perneczky R
• 通讯作者: Perneczky R