Comprehensive analysis of the gene expression changes related to cytomegalovirus infection in the placenta

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Human cytomegalovirus (HCMV) infection to pregnant women causes congenital infection to the fetus through the placenta. The virological analysis in placenta was performed using guinea pig and guinea pig CMV (GPCMV) model. In this study, the guinea pig placental tissue culture system and the system of quantitative measurement of changes in the gene in infected guinea pig placenta were established. By the quantitative analysis of the gene expression change in the infected placenta and cultured cell, the gene expression change was associated with the GPCMV infection. A gene expression change was recognized early in infection in the cultured cell.