Carcinogenesis of ovarian clear cell adenocarcinoma

卵巢透明细胞腺癌（CCA）常与子宫内膜异位症相关，而与腺纤维瘤相关较少。我们研究了在腺纤维瘤相关的CCA中编码ARID1A的BAF250a的表达缺失，并与子宫内膜异位症相关的CCA进行了比较。与子宫内膜异位症单独CCA相比，腺纤维瘤单独CCA中BAF250a表达缺失的频率明显较低。

Ovarian clear cell adenocarcinoma (CCA) is frequently associated with endometriosis, and less often with adenofibroma. We investigated loss of BAF250a expression, which is encoded ARID1A, in adenofibroma-related CCA and compared with that in endometriosis-related CCA. Loss of BAF250a expression was significantly less frequent in adenofibroma alone CCA compared with endometriosis alone CCA.