Angiogenesis in human ovary and infertility treatment

妊娠成功组血清和卵泡液AMH水平均高于妊娠失败组。虽然血清和卵泡液中的AMH水平之间存在显著的相关性，但在一些单独在卵泡液或血清中AMH水平升高的患者中观察到了差异。血清或卵泡液中AMH水平的升高似乎预示着成功妊娠，即使其他激素水平较低。Netrin-1反映了卵巢血管生成的状态和OHSS的出现。根据体外分析，Netrin-1可能在较低浓度下下调卵巢血管生成。内皮抑素在卵巢中的分布呈正态分布，其水平与卵巢刺激的进程无关，可能具有稳定卵巢血管生成的作用。

Both the serum and follicular fluid AMH levels were higher in the successful pregnancy group than in the failed pregnancy group. While a significant correlation was found between the serum and follicular fluid AMH levels, however, a discrepancy was observed in some patients with elevated AMH levels in the follicular fluid or serum alone. Elevated AMH levels in either the serum or follicular fluid appeared to be predictive of successful pregnancy, even if the other hormone levels were low.Netrin-1 reflects the state of ovarian angiogenesis and appearance of OHSS. Depending on the in vitro analysis, netrin-1 may down regulate the ovarian angiogenesis in lower concentrations. The distribution of endostatin was normality and the levels did not depend on the course of ovarian stimulation, thus the endostatin may stabilize the angiogenesis in ovary.