risperidone supress cocaine-induced hyperthermia and dopamine level increasing in rat

可卡因是一种非法的精神刺激剂，在全球范围内被广泛使用。体温过高与可卡因致死效应密切相关。据报道，可卡因引起体温升高主要是通过释放DA来实现的。我们假设利培酮可以抑制可卡因引起的体温升高。可卡因公司。大鼠注射利培酮后体温升高，利培酮可明显抑制体温升高。D1型和5HT2A型受体拮抗剂可预防可卡因诱导的体温升高，因此利培酮预防可卡因诱导的体温升高的作用可能主要归因于其D1型和5HT2A型受体拮抗剂。可卡因使下丘脑前部DA、5-羟色胺和去甲肾上腺素水平升高，利培酮可显著抑制可卡因引起的DA水平升高，提示利培酮是治疗可卡因引起的急性体温升高的有效药物。

Cocaine, an illegal psychostimulant, is widely used globally. Hyperthermia is closely related to cocaine lethality effect. Cocaine has been reported to induce hyperthermia mainly by causing DA release. We hypothesized that risperidone could suppress cocaine-induced hyperthermia. Cocaine s.c. injection induced hyperthermia in rats, which was significantly suppressed by the injected risperidone. D1 and 5-HT2A receptor antagonists prevent cocaine-induced hyperthermia; thus,risperidone`s ability to prevent cocaine-induced hyperthermia might be mainly attributable to its D1 and 5-HT2A receptor antagonism.In the microdialysis study, we found that i.p. cocaine administration increased DA, 5-HT, and NA levels in the anterior hypothalamus, and that risperidone pretreatment significantly suppressed the cocaine-induced increase in DA levels.Our results indicate that risperidone is a potentially useful drug for treating cocaine-induced acute hyperthermia in humans.