Foundation of infection control strategy for implantitis with nanonetwork structure

种植体周围炎可导致种植体骨结合失败。脂多糖（LPS）作为一种慢性刺激，维持种植体周围炎症，从而恶化种植体骨整合的预后。为探讨牙龈卟啉单胞菌脂多糖（P.gingivalis LPS）对骨髓间充质干细胞（BMMSCs）在纳米网状钛表面增殖和成骨分化的影响，将经10 M NaOH溶液处理的钛片和未经处理的对照钛片与BMMSCs共同孵育，然后暴露于牙龈卟啉单胞菌脂多糖（P.gingivalis LPS）中。在不同浓度的牙龈卟啉单胞菌脂多糖（LPS）刺激下，纳米网结构钛表面的BMMSCs增殖和分化能力均显著高于对照表面，纳米网结构钛表面对内毒素的耐受能力也优于未修饰表面。

Peri-implantitis can result in failure of implant osseointegration. Lipopolysaccharides (LPS) act as a chronic stimulus, maintaining peri-implant inflammation and thereby worsening the prognosis for implant osseointegration. The purpose of this study was to determine the effect of Porphyromonas gingivalis (P. gingivalis) LPS on the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs) on a nanonetwork titanium surface.Titanium disks treated with 10 M NaOH solution and untreated control disks were incubated with BMMSCs and then exposed to P. gingivalis LPS. The BMMSCs on the nanonetwork titanium surface with nanonetwork structure had significantly higher cell proliferation and cell differentiation when exposed to P. gingivalis LPS at different concentrations than cells on the control surfaces.The nanonetwork titanium surface had better endotoxin tolerance under P. gingivalis LPS exposure than non-modified surfaces.